منابع مشابه
Targeted Therapies in Epithelial Ovarian Cancer
Molecularly targeted therapy is relatively new to ovarian cancer despite the unquestionable success with these agents in other solid tumours such as breast and colorectal cancer. Advanced ovarian cancer is chemosensitive and patients can survive several years on treatment. However chemotherapy diminishes in efficacy over time whilst toxicities persist. Newer biological agents that target explic...
متن کاملNovel Targeted Therapies in Ovarian Cancer
Background: Traditional management of women with advanced ovarian cancer with surgery and chemotherapy provides limited duration of survival. Targeting specific pathways in angiogenesis or DNA repair may provide therapeutic benefit. Results: In this manuscript, we review the use of various compounds including antibodies that target specific growth factors receptors or ligands for receptors as w...
متن کاملOvarian cancer: emerging molecular-targeted therapies
With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring disease is almost always lethal, and only about 30% of the women affected will be cured. Thanks to a better understanding of the molecular mechanisms underlyi...
متن کاملTargeted Therapies in Epithelial Ovarian Cancer
Epithelial ovarian cancer remains a major women's health problem due to its high lethality. Despite great efforts to develop effective prevention and early detection strategies, most patients are still diagnosed at advanced stages of disease. This pattern of late presentation has resulted in significant challenges in terms of designing effective therapies to achieve long-term cure. One potentia...
متن کاملPseudotyped αvβ6 integrin-targeted adenovirus vectors for ovarian cancer therapies
Encouraging results from recent clinical trials are revitalizing the field of oncolytic virotherapies. Human adenovirus type 5 (HAdV-C5/Ad5) is a common vector for its ease of manipulation, high production titers and capacity to transduce multiple cell types. However, effective clinical applications are hindered by poor tumor-selectivity and vector neutralization. We generated Ad5/kn48 by pseud...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Obstetrics & Gynaecology
سال: 2017
ISSN: 1521-6934
DOI: 10.1016/j.bpobgyn.2016.12.001